Endocrine Abstracts

Cushing’s syndrome results from an excess exposure to glucocorticoids which can result from various causes, divided into ACTH-dependent and ACTH-independent etiologies. An example of ACTH-independent causes are adrenal masses which are either benign adenomas, representing the majority of adrenal mass cases, or by malignant neoplasms. We present the case of a 52 yo woman who presented at the Emergency Department (ER) with thoracic pain and palpitations, for which several c...

Introduction: The prevalence of functioning gonadotropinoma is difficult to assess since most of reports are case reports. Gonadotropinomas rarely lead to a noticeable clinical syndrome. They usually produce symptoms associated with mass effect such as headaches, visual field impairment and hormonal deficiencies.Case report: We present the case of a 38 years old women diagnosed in 2017 with microprolactinoma. She had elevated prolactin level (108 ng/ml) ...

Introduction: Cryptorchidism is unilateral or bilateral absence of the testes from the scrotum. One of the differential diagnosis is congenital bilateral anorchia. Vanishing testes syndrome is associated with low serum AMH concentrations and an absent or subnormal response to stimulation with hCG. We report the case of a 22-year-old boy diagnosted with bilateral cryptorchidism and hypergonadotropic hypogonadism at the age of 17 years old. At the time of diagnosis the scrotum w...

Introduction: Primary hyperparathyroidism is typically caused by a parathyroid adenoma (80-85% of the cases). Very rare causes are represented by parathyroid carcinoma and atypical parathyroid adenoma (0.5-1.5% of the cases). Atypical parathyroid adenomas have atypical histological features, not sufficient to be considered a carcinoma, and have an uncertain malignant potential and risk of recurrence. We report the case of a 66-year-old man referred from another medical center ...

X-linked hypophosphatemia is a rare inherited disorder, yet the most common among the inherited causes of rickets. It is caused by different mutations in the PHEX gene leading to an impaired regulation of fibroblast growth factor 23 (FGF 23) and renal phosphate wasting. Patients with XLH show multiple musculoskeletal complications which usually can lead to early diagnosis in childhood. Nevertheless XLH is a lifelong disease, with multisystemic manifestations, including entheso...

Background: The rapid advancements in the field of allogenic hematopoietic stem cell transplantation (allo-HSCT) and better management of acute postprocedural complications have led to increased life expectancy, but at the same time to higher incidences of long-term complications. Conditioning regimens (chemotherapy, total body irradiation), immunosuppresive treatments and immune dysregulation threaten endocrine and metabolic functions, leading to late effects, including hypog...

Cushing’s syndrome, whether it is ACTH-dependent or ACTH-independent, causes many complications due to chronic exposure of tissues to a glucocorticoid excess. Some of these are arterial hypertension, obesity, osteoporosis, coagulopathies, impaired glucose tolerance and diabetes. We present a case of Cushing’s syndrome diagnosed in a 64-year-old female that was referred to the Endocrinology Department from the Physical Medicine and Rehabilitation Department due to mul...